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The pharmaceutical industry has at least one thing in common with the movie and book-publishing industries companies in all three industries live or die based on the success of one or two blockbusters every year or two. In the pharmaceutical industry, a blockbuster is a drug that can fetch $1 billion or more in annual revenue, such as SmithKline s Tagamet , Glaxo s Zantac , Syntex s Naprosyn , and Bristol-Meyers Capoten . When a new drug looks like it has a good chance of making it through the regulatory gauntlet, the pharmaceutical rm that developed the drug typically pours tens to hundreds of millions of dollars into a marketing and education campaign that crescendoes with the launch of the drug. The goal is to make as much pro t from the drug as possible before the patent on the drug expires and competition from generics dilute pro ts. According to the Pharmaceutical Research and Manufactures of America s (PhRMA), Pharmaceutical Industry Pro le 2002, patent protection for a newly re leased drug expires, on average, 11 to 12 years after the release of a drug. Pharmaceutical rms survive with the blockbuster model of doing business, by lling the regulatory pipeline with new drugs, by nding new indications for drugs already on the market, by developing new formula tions of proven blockbuster drugs, and through a variety of legal and reg ulatory maneuvers. Another popular way to acquire a continuous stream of revenue from a blockbuster drug is for the pharmaceutical rm to merge with a pharmaceutical company with an existing blockbuster drug in its pipeline. This method of tapping into a signi cant revenue stream is so popular that a pharmaceutical rm that hasn t been acquired or that

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where N 1 is an integer. The particles are placed in a unit square of [0,1] x [0, 1]. If no is the number of particles per unit area, then

(9.2.2)

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Using Class Designer can improve your productivity if you prefer a visual model for creating your classes, properties, and methods Using snippets can provide a huge time savings, both in minimizing typing for common tasks and in negating the need to look up syntax for less frequently used tasks Using the unit testing tools in Visual Studio Team System (or a tool such as NUnit with other editions of Visual Studio) helps ensure that you deliver high-quality code and don t need to spend as much time xing bugs, because you will have found and xed the majority of them during your unit testing Implementing lists of objects using generics signi cantly minimizes the amount of code you need to manage the list

Let b be the diameter of the particle, with b = 2a, where a is the radius of the particle. Let 1 be the fractional area occupied by the particles. In the computer code, we specify Nand f. Then the diameter b is

(9.2.3)

Inside the square, we first placed the particles periodically in both directions with spacing 8 given by 1

(9.2.4)

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The next chapter details how the user interface can use the business objects by implementing object binding

(9.2.5)

838) 2'2 2'2 1) 38) (2'2 ' (38 38) ' (58 38) ,... , ((N 2 8'2

isn t acquiring another rm is the exception rather than the rule Because of their massive economic impact on local and regional economies, most mergers of the pharmaceutical titans warranted front-page coverage in the popular press, as well as the attention of the various antitrust regula tory agencies As an indication of the frequency of mergers in the pharmaceutical in dustry, consider the frenzied merger activity over the past decade, which is actually a continuation of activity over the past century For example, the UK drug companies Glaxo Wellcome and SmithKlineBeecham PLC merged in 2000 to form the largest drug company in the world, and the largest company in the United Kingdom Similarly, Glaxo Wellcome was formed by a merger of Glaxo and Wellcome in 1995, at the time the largest merger in the United Kingdom SmithKlineBeecham PLC was formed by the merger of the US.

(9.2.6)

and so on. To generate the Oth realization, we use shuffling. We perform N pass passes. For each pass, there is an attempt to move each particle once even

If you are building along with the Purchase Tracker sample application, this chapter added classes to your business object component It optionally added a unit test project to your solution for unit testing of your business object class s properties and methods Since the user interface from the preceding chapter does not yet reference any information in the business object component, running the application provides the same results as at the end of the preceding chapter However, if you created the unit test project, you can now test your business objects

(9.2.7)

where Cst is an adjustable constant for the displacement. For a particle j with coordinates (x j , Yj) we generate its possible new coordinates (xj, yj) from two random numbers rl and r2 that are randomly and uniformly distributed between -1 and 1. In MATLAB, the function rand can be used to generate rl and r2

(9.2.8) (9.2.9)

Next we need to check whether the new coordinates, (xj, Yj), are acceptable by making sure that they do not overlap with other particles. Note that the periodic boundary conditions are used. Thus each particle has images in other squares. To check for overlap with particle l, (l = 1,2, ... , Nand l -I j), we calculate

(9.2.10)

6

Do the same for r y = YI - Yj, with the appropriate replacements. Then we calculate the distance between particles j and l

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